Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.5
USERS' SCORE
Good
Based on 16 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
9
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
Most Useful Reviews
9.5
Essential daily intake
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
Read More
9.5
Supports heart health
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Read More
8.8
Aids nerve health
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.5
- All Researches
9
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how cow’s milk intake influences the risk of coronary heart disease (CHD) in postmenopausal women. Analyzing data from the Korea National Health and Nutrition Examination Survey, we included 1,825 women aged 50–64.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Essential daily intake
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
Read More
9.5
Supports heart health
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Read More
8.8
Aids nerve health
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
Read More
10
Relieves pain
I experienced bone pain and fatigue from vitamin deficiency. After taking B-12, my condition improved significantly.
Read More
8.8
Boosts energy levels
I appreciate the easy absorption and energy boost from this vitamin. Methyl cobalamin is more effectively absorbed, aiding energy production and maintaining vital DNA functions, which can help prevent heart disease.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. doi:10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. doi:10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. doi:10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. doi:10.3390/ijms222111737
- Aggarwal P, Sinha SK, Khanra D, Razi M, Nath RK, et al. Hematinic deficiency in patients with heart failure with reduced ejection fraction (HFrEF). Ann Cardiol Angeiol (Paris). 2022;71:153. doi:10.1016/j.ancard.2021.09.014
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. doi:10.1016/j.ymgmr.2024.101089
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. doi:10.2174/1573403X19666230209111854
